Iain Turner and Doyle Middleton returned from injury to start the match against Macclesfield.
Preston took the lead in the 13th minute with a goal from George Miller. Twenty minutes later saw the lead doubled with a Bailey Wright goal.
Danny Mayor made it 3-0 on 67 minutes before the Silkman pulled one back five minutes later via Tom Fisher.
Michael McLellan made it 4-1 on 77 minutes for the Lilywhites.
Preston lead the table on 9 points from 4 matches.
Morecambe are second with 6 points after 3 matches after a 4-1 victory over Oldham.
Then it's Burnley, Wrexham, Oldham and Macclesfield on 4 points.
PNE's next opponents Tranmere prop up the table on 3 points after a 3-0 defeat at Wrexham.