A second half header from Sam Osobe gave victory for the Lilywhites over Carlisle.
Earlier in the week saw PNE win 2-1 against Rochdale at Ashton United's ground.
PNE took the lead on 5 minutes from Naim El-Harrati. Rochdale equalised later in the half. On 70 minutes Will Hayhurst was brought down in the penalty box and converted the penalty himself.
Preston are on 47 points from 20 matches. Burnley are second on 45 points but have played 18 matches. Wallsall are third with 44 points from 19 matches after a 1-1 draw at Macclesfield.