It was Blackpool who took the lead with a goal from Jamie Menagh before a Brandon Zibaka brace in quick succession gave the Lilywhites a 2-1 interval lead.
Blackpool equalised through Garen Tchobanion before Luke Clark scored Preston's third around the hour mark.
Since the opening day defeat Preston have won four and drawn one to lead the table on 13 points from 6 matches. Whilst Blackpool have lost four and drawn one in the same period.
Only two other matches were played on Saturday with Walsall continuing their 100% record with a 2-0 victory over Macclesfield leaving the Saddlers just one pont behind PNE but with two matches in hand.
Carlisle have moved upto third on goal difference with a 3-1 win at Tranmere.
Walsall have a chance to go top next weekend with a home match against Wrexham, whilst PME next game is not until 24th September at Bury.