Follow the M3 to the end exiting at s/p m27 west, Southampton docks. After 3/4 of a mile where the road forks bear left onto the A33 s/p Southampton. At second roundabout take the first exit into Bassett Avenue which becomes the Avenue and then Dorset Street. At the roundabout take the second exit (Dorset Street) and follow the road round to Junction with Street Mary's Kingsway. Take this right and then first left in to Chapel Street and left again in to Melbourne Street.
From the East:
Exit the M27 at Junction 7 take the 1st exit. At the roundabout take the 3rd exit (signposted "City Centre") Bursledon Road A3024.Follow the signs for the City Centre until you reach Northam Bridge (Merdian TV Studios will be on you're right). At the next set of traffic lights turn left into Prince's Street and follow it round into Millbank Street carry straight on into Belvidere Road. The stadium is on the right hand side.
From the West:
Exit the M27 at Junction 3 and take the M271 to Millbrook. Follow signs to the City Centre. Passing by Southampton Train Station follow road to the top of hill. Go straight on past the Civic Centre to the traffic lights then follow New Road. Carry straight on into Northam Road, pass the Gas Tanks and take next right into Britannia Road. the Stadium is on the right.
If you don't fancy the long journey in the car there is always the option of the train although you will still have to set off early! The train station is not far from the ground and maybe the more favoured option. The plane is also another cheap option with flights down to Southampton airport.
Preston have only played once at St. Mary's which was last season in a 0-0 draw in a midweek game. Paul Simpson will be looking for something similar from Saturday's game.