Wiseman, Welsh and Humphrey all returned to the starting line up as Preston secured a two nil win thanks to a first league goal from Callum Robinson and another from Paul Huntington. Jamie Jones also kept the visitors in the game at Orient.
Preston now travel to Rochdale on Saturday sitting in second place five points clear of the play off pack but only two behind Bristol City with a game in hand to be played next Tuesday away at Swindon.